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https://mp.weixin.qq.com/s/QZAOQd_XuiXQN92ZpbEN_w

近日，华南农大张彤-陈四平团队在JAFC发表了题为《Rice Stripe Mosaic Virus Encoded P6 Interacts with Heading Protein OsHAPL1 to Promote Viral Infection》的研究论文，揭示了水稻条纹花叶病毒编码的P6与抽穗蛋白OsHAPL1相互作用促进病毒感染。

水稻条纹花叶病毒（RSMV）是已知的唯一能在自然感染的水稻植株中观察到的细胞质核糖体病毒。它编码P6蛋白，诱导感染的水稻植株的抽穗延迟并降低水稻的产量。

在本研究中，作者发现RSMV的P6与OsHAPL1相互作用，促进了OsHAPL1与DTH8之间的相互作用，导致在长日照条件下水稻抽穗延迟。

此外，OsHAPL1在RSMV感染中扮演双重角色，既正调控病毒感染，又负调控防御信号基因的表达。

这些发现阐明了一种新的分子机制，即病毒如何操纵宿主防御系统以增强病毒感染和传播，为水稻抽穗与病毒抗性途径之间的交叉互作提供了新见解。

Rice stripe mosaic virus (RSMV) is the sole cytoplasmic rhabdovirus documented in naturally infected rice plants. It encodes P6, which induces delayed heading and reduces yield in infected rice plants. P6 of RSMV interacts with OsHAPL1, facilitating the interaction between OsHAPL1 and DTH8, resulting in delayed rice heading under long day conditions. Additionally, OsHAPL1 plays a dual role in RSMV infection by positively influencing viral infection while negatively regulating the expression of defense signal genes. These findings elucidate a novel molecular mechanism through which a virus manipulates the host defense system to enhance viral infection and transmission, shedding new light on the crosstalk between rice heading and disease resistance pathways.

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